Jan 3, 2024 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting...

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar.

Mar 13, 2025 · Guanosine triphosphate (GTP) is essential in translation, providing energy and regulating ribosomal function. Beyond energy transfer, it influences accuracy and efficiency in protein synthesis. Understanding GTP’s role in translation offers insight into cellular control mechanisms and potential therapeutic targets.

GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). [1] The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein domain common to many GTPases. [1]

Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene expression and many other significant events in cells, such as the interaction with foreign particles.

Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP‐binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases.

Jun 3, 2010 · In this study, for the first time, we have introduced new concept for generating patterns for predicting dipeptide (two consecutive GTP interacting residues) and tripeptide (three consecutive GTP interacting residues) from a single pattern.

Jul 16, 2015 · We describe here the synthesis of reactive acryl derivatives of guanine nucleotides that are able to react covalently with strategically placed cysteines in GTPases to lock them into their...

Jun 16, 2022 · GTP is essential for nuclear acid biosynthesis. In addition, through its effects on G proteins, GTP regulates a large array of cellular processes including protein synthesis, cytoskeleton biogenesis and function, and intracellular signaling.

Apr 18, 2013 · We identified several classes of genome-encoded GTP aptamers using this approach, the most abundant of which (the “G motif”) adopts a G-quadruplex structure. Further analysis revealed that virtually all G-quadruplexes of both RNA and DNA bind GTP.