In probability theory, the Mills ratio (or Mills's ratio [1]) of a continuous random variable is the function ():= ¯ (), where () is the probability density function, and

Jul 8, 2016 · The length of exons 3–9 of MLL is ~12.5 kb, suggesting that SNP-arrays can identify the MLL-PTD alteration. Indeed, canonical MLL-PTD involving exons 3–9 was identified in the EOL-1 (known to carry MLL-PTD mutation 29), as well as the Kasumi-6 AML cell line (Supplementary Figures 15c and d).

Indeed, the MLL WT/MLL-AF9 transcript ratio varied from nearly equivalent levels (ratio = 0.87) to a ratio of 11.8 . These data suggest that silencing of the MLL WT allelic expression is unique to MLL PTD/WT AML.

In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and the clinical manifestations of this group of leukemias.

During APA treatment, morphological features of granulocytes in peripheral blood were suggestive of in vivo differentiation of AML blasts and, therefore, we quantified MLL-PTD ratio from isolated granulocytes during APA. Granulocytes were isolated from peripheral blood by autofluorescence-based fluorescence-activated cell sorting (FACS) and MLL ...

Dec 15, 2014 · Consider the Mills ratio f (x) = (1 − Φ (x)) / ϕ (x), x ≥ 0, where ϕ is the density function of the standard Gaussian law and Φ its cumulative distribution. We introduce a general procedure to approximate f on the whole [0, ∞) which allows to …

Mar 2, 2021 · Is there anything we can say about limx→∞ F(x) f(x) lim x → ∞ F (x) f (x) where F(x) F (x) is the CDF of the normal distribution and f(x) f (x) is the pdf? I know this function is increasing, but what can we say about the limit?

Dec 2, 2022 · Stem cell transplantation (SCT) was a favorable independent prognostic factor affecting event-free survival (EFS) in MLL-r positive patients (P = 0.027), and there was a trend toward an independent prognostic effect on overall survival (OS) (P = 0.065).

We propose two novel likelihood ratio tests that can be evaluated at any time points: (i) the expected MLL ratio and (ii) the noisy posterior concentration (NPC) ratio.

Oct 29, 2024 · We propose MLL oncoproteins promote lineage-switching events through dynamic chromatin binding at lineage-specific target genes, and may support resistance to menin inhibitors through similar...