Mar 30, 2025 · ERCC4 (ERCC Excision Repair 4, Endonuclease Catalytic Subunit) is a Protein Coding gene. Diseases associated with ERCC4 include Xfe Progeroid Syndrome and Fanconi Anemia, Complementation Group Q. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

Mar 30, 2025 · Complete information for ERCC1 gene (Protein Coding), ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit, including: function, proteins, disorders, pathways, orthologs, and expression.

Mar 30, 2025 · NTHL1 (Nth Like DNA Glycosylase 1) is a Protein Coding gene. Diseases associated with NTHL1 include Familial Adenomatous Polyposis 3 and Inherited Cancer-Predisposing Syndrome.

Mar 30, 2025 · This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks.

Mar 30, 2025 · Complete information for SLX4 gene (Protein Coding), SLX4 Structure-Specific Endonuclease Subunit, including: function, proteins, disorders, pathways, orthologs, and expression.

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Mar 30, 2025 · Complete information for EME2 gene (Protein Coding), Essential Meiotic Structure-Specific Endonuclease Subunit 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Mar 30, 2025 · Complete information for ERCC3 gene (Protein Coding), ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit, including: function, proteins, disorders, pathways, orthologs, and expression.

Mar 30, 2025 · Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure.

Mar 30, 2025 · Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed: 32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria.