DNA-damage repair; the good, the bad, and the ugly - PMC
In the absence or impairment of such repair or checkpoint mechanisms, the genomic integrity of the organism is often compromised. This review will focus on the functional consequences of …
DNA Repair - Molecular Biology of the Cell - NCBI Bookshelf
Because of the importance of maintaining intact, undamaged DNA from generation to generation, cells have an additional mechanism that helps them respond to DNA damage: they delay …
Mechanisms of DNA damage, repair and mutagenesis - PMC
At least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR) and non-homologous end …
Involvement of Nucleotide Excision and Mismatch Repair …
DSBs make cells more prone to unsuccessful DNA repair due to the lack of a complementary template, especially in G1 phase cells. Unrepaired DNA damage may cause cell cycle arrest …
Base Excision Repair Pathway: How Cells Fix DNA Damage
Mar 11, 2025 · In long-patch BER, DNA ligase I performs ligation, working with proliferating cell nuclear antigen (PCNA) to process longer repair tracts. Proper ligation restores DNA continuity …
Alpha-synuclein regulates nucleolar DNA double-strand break repair …
Apr 9, 2025 · We unexpectedly found that αSyn colocalized with DNA double-strand break (DSB) repair components within the nucleus of human and mouse cells. αSyn knockout (KO) …
DNA repair and genetic instability - World Cancer Report - NCBI …
Multiple, redundant DNA damage repair and signalling pathways combine to avoid errors during DNA replication and to remove DNA lesions from endogenous or exogenous sources. This …
How human cells repair damaged DNA | ETH Zurich - ETH Zürich
Apr 9, 2025 · However, repair mechanisms not only defend against external threats; they also play a crucial role in helping cells survive the challenges they face in their daily fight for …
Rewriting the rules of DNA repair - A*STAR Research
Mar 17, 2025 · Now a PhD candidate at the Cancer Research UK (CRUK) Cambridge Institute, Goh’s work in genome engineering focuses on DNA damage repair (DDR): how our cells try to …
Understanding DNA repair: How a 'twisting switch' and SUMO4 …
3 days ago · Research has elucidated two critical DNA repair mechanisms. A "twisting switch" regulates the DNA repair protein RNF168, preventing excessive signaling and ensuring proper …