Mar 6, 2024 · Ventricular tachycardia is a type of irregular heartbeat, called an arrhythmia. It starts in the lower chambers of the heart, called the ventricles. This condition also may be called V-tach or VT. A healthy heart typically beats about 60 to 100 times a minute at rest.

The transverse aortic constriction model (or TAC banding model) results in left-sided heart failure through pressure overload partial occlusion of the transverse aorta. This procedure often leads to cardiac hypertrophy, a common compensatory mechanism in heart failure and, in some animals, will result in heart failure over time.

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model for pressure overload-induced cardiac hypertrophy and heart failure. 1 TAC initially leads to compensated hypertrophy of the heart, which often is associated with a temporary enhancement of cardiac contractility.

Apr 10, 2019 · Transverse aortic constriction (TAC) is a well-established model of pressure overload-induced cardiac hypertrophy and failure in mice. The degree of constriction “tightness” dictates the TAC...

In the mouse transverse aortic constriction (TAC) is used to induce pressure overload and somewhat mimic the condition of hypertension in humans, causing LV hypertrophy and subsequent heart failure (Rockman et al., 1991).

Transverse aortic constriction (TAC) in mice is one of the most commonly used surgical techniques for experimental investigation of pressure overload-induced left ventricular hypertrophy (LVH) and its progression to heart failure.

Apr 25, 2020 · The transverse aortic constriction (TAC) model is frequently used to study adverse cardiac remodeling upon pressure overload. We set out to define the most important characteristics that define the degree of cardiac remodeling in this model.

Introduction: Murine transverse aortic constriction (TAC) is a frequently used model of pressure overload-induced left ventricular (LV) remodeling. However, there is considerable variability in disease progression to overt heart failure (HF) development in the most commonly used strain of mice (i.e., C57BL/6J).

Apr 21, 2010 · Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model for pressure overload-induced cardiac hypertrophy and heart failure. TAC initially leads to compensated hypertrophy of the heart, which often is associated with a temporary enhancement of cardiac contractility.

Oct 30, 2018 · In our model, transverse aorta constriction (TAC) 12, 13 in 8-week-old C57BL/6 mice induced cardiac hypertrophy at 1–2 weeks after the operation and heart failure at 4–8 weeks (Fig. 1a and...