Sialic acids are a class of alpha-keto acid sugars with a nine-carbon backbone. [1] The term "sialic acid" (from Greek σίαλον (síalon) ' saliva ' ) was first introduced by Swedish biochemist Gunnar Blix in 1952.

Sialic acids are found on circulating glycoprotein hormones such as those originating from the pituitary gland [luteinizing hormone (LH) and follicle-stimulating hormone (FSH)] and from the placenta [human chorionic gonadotropin (hCG)].

Sep 30, 2024 · In this review, we aimed to summarize the biological functions of sialic acid and the process of sialylation, explore their roles in various pathophysiological contexts, and discuss their ...

Sialic acids (Sias) are abundant on vertebrate glycoproteins, glycolipids, and milk oligosaccharides, as well as on some microbial surface glycans, mediating diverse functional roles.

Most Sias are composed of N-acetylneuraminic acid (Neu5Ac, >99%), and Sia is its most commonly used name. In this article, we review Sias in terms of their structures, applications, determination methods, metabolism, and production strategies.

The potential of sialic acid as a crucial routine marker in different pathological conditions warrants exploration. Sialic acid and associated enzymes are promising therapeutic targets for improving anticancer and antiviral drugs and medications for CVD, neurological disorders, and diabetic complications. Acknowledgments

Feb 26, 2025 · Sialic acid (SA) is widely present at the end of the sugar chain of glycoproteins and glycolipids on the surface of animal and microbial cells and is involved in many physiological activities...

Jan 15, 2022 · Sialic acids can act as potent immune modulators on the surface of cancer cells, providing an immunosuppressive microenvironment and tumour immune evasion. Sialic acid-blocking glycomimetics such as Ac 5 3F ax Neu5Ac (Büll et al., 2018) enables strong tumour immune responses.

Jan 1, 2021 · Sialic acids (Sias) are negatively charged functional monosaccharides present in a wide variety of natural sources (plants, animals and microorganisms).

Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially of higher animals. In this exposed position they contribute significantly to the structural properties of these molecules, both in solution and on cell surfaces.