SV40 consists of an unenveloped icosahedral virion with a closed circular double-stranded DNA genome [15] of 5.2 kb. [16] Structurally, SV40 is composed of 72 pentamers of major capsid protein VP1, with each VP1 pentamers harboring one minor capsid protein, either VP2 or VP3.

Duplication of the simian virus 40 (SV40) genome is the best understood eukaryotic DNA replication process to date. Like most prokaryotic genomes, the SV40 genome is a circular duplex DNA organized in a single replicon.

The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in ...

SV40 shares about 70–75% genome homology with JCPyV (10–12) and BKPyV (12, 13), whereas it has little homology with other HPyVs, including HPyV 6 and 7 , Malawi polyomavirus (MXPyV or HPyV 10) , Saint Louis polyomavirus (STPyV or HPyV 11) , and Merkel cell polyomavirus (MCPyV) (17–19).

Mar 1, 2025 · Simian Virus 40 (SV40), a prototypical polyomavirus, has been a cornerstone of DNA virus molecular biology for the past 65 years. Recent advancements have shed light on several key processes.

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types.

SV40 genome replicates inside the nucleus of the cell, but the capsid protein are synthesized in the cytoplasm and migrate inside the nucleus where, finally, the assembly of the virus take place. The replication of SV40 genome can be divided into two distinct stages: early and late.

Jan 1, 1981 · Simian virus 40 (SV40) in particular has attracted wide attention because it can transform infected cells in living animals or cells in culture to tumorigenicity. The recent discovery that SV40 genome has a chromatin-like structure has further stimulated interest in this virus.

Jan 20, 1999 · SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. This virus has been a favored laboratory model for mechanistic studies of molecular …

Feb 20, 2009 · Duplication of the simian virus 40 (SV40) genome is the best understood eukaryotic DNA replication process to date. Like most prokaryotic genomes, the SV40 genome is a circular duplex DNA organized in a single replicon.