It regulates the synthesis and activity of DNA repair proteins (SOS induction), participates in mutagenesis, and promotes the central steps of DNA pairing and strand exchange in genetic recombination and recombinational DNA repair.

SOS repair refers to the DNA repair mechanism, which makes the use of RecA regulatory protein, to inhibit the repressor activity and to activate the SOS inducer genes to recover DNA damage.

The SOS response is a global transcriptional response to DNA damage in prokaryotes, in which the cell cycle is arrested and DNA repair mechanisms (error-free as well as error-prone) are induced. The regulation of this response is driven by two proteins, RecA and LexA .

An SOS response is triggered when single-stranded DNA (ssDNA) is present in the cell, which is one of the consequences of DNA damage. Repair of double-stranded DNA (dsDNA) breaks is a fundamental aspect of genome conservation.

The SOS-system is a global response to DNA damage that leads to the increased expression of genes involved in DNA repair and survival of the bacterial cell; it is regulated by two proteins, LexA and RecA. LexA is a repressor that binds to the promoter regions of SOS-response regulatory genes.

The SOS response has become a paradigm for the field of DNA repair. During the past 30 years, several laboratories have addressed questions concerning the function of the SOS genes and mechanisms that fine-tune their regulation.

Jun 1, 2024 · What is SOS Response or SOS Repair? The SOS response, a pivotal cellular mechanism, is activated in response to DNA damage. This intricate system momentarily halts the cell cycle, facilitating DNA repair and mutagenesis. Central to this system is the RecA protein, analogous to Rad51 in eukaryotes.

Sep 23, 2008 · The SOS response was the first DNA repair system described in Escherichia coli induced upon treatment of bacteria with DNA damaging agents arrest DNA replication and cell division. Induction of the SOS response involves more than forty independent SOS genes, most of which encode proteins engaged in protection, repair, replication, mutagenesis ...

Escherichia coli, among other bacteria, has evolved an inducible system, termed the SOS response, which allows it to survive sudden increases in DNA damage. The term SOS response was first introduced in the 1970s by Miroslav. Radman (1974).

Dec 1, 2020 · In the present review, we focus on the central role of SOS response in bacterial resistance mechanisms and its potential as a new target for control of resistant pathogens. 1. Introduction.