Nov 11, 2011 · We found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. The preference for succinyl and malonyl groups was explained by the presence of an …

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the …

Jun 5, 2022 · SIRT5 targets hundreds of protein substrates that are involved in various pathways that regulate different physiological processes, including tricarboxylic acid cycle (TCA cycle), …

Oct 9, 2024 · SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD + -binding pocket. SIRT5, one of the mammalian sirtuins, specifically recognizes …

Here, we present two more structures: a binary complex of SIRT5 with an H3K9 succinyl peptide and a binary complex of SIRT5 with a bicyclic intermediate obtained by incubating SIRT5 …

Dec 17, 2019 · Co-crystallization of sensitive substrates P13 and P15 with SIRT5 revealed an unexpected binding mode, involving interactions with residues from active site bordering …

Apr 14, 2011 · We found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. The preference for succinyl and malonyl groups was explained by the presence of an …

Jun 5, 2022 · Herein, we present an overview of the structure and biological function of SIRT5 as well as the advances in SIRT5 inhibitors research. We also provide insights for the future …

Know comprehensive SIRT5 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Here we found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. The preference for succinyl and malonyl groups was explained by the presence of an arginine …