May 4, 2020 · Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter...

Sep 15, 2006 · General structure A of lipoteichoic acid (LTA) from Staphylococcus aureus (A) and structure of closely related compound 1a and its diastereoisomer 1b. Download: Download full-size image; Scheme 2. Structure of target molecule …

Jan 9, 2025 · Staphylococcus aureus synthesizes polyglycerol-phosphate lipoteichoic acid (LTA) from phosphatidylglycerol. LtaS, a predicted membrane protein with 5 N-terminal transmembrane helices followed by a large extracellular part (eLtaS), …

May 15, 2007 · Construction of a mutant S. aureus strain with inducible ltaS expression revealed that LTA synthesis is required for bacterial growth and cell division. An ltaS homologue of Bacillus subtilis restored LTA synthesis and the growth of ltaS mutant staphylococci.

Genetically engineered mutants lacking LTA have been constructed in S. aureus and Lactobacillus acidophilus . These results suggested a dispensable nature of WTA or LTA in Gram-positive bacteria. Alternatively, other macromolecules in the cell …

Staphylococcus aureus lipoteichoic acid (LTA) is composed of a linear 1,3-linked polyglycerolphosphate chain and is tethered to the bacterial membrane by a glycolipid...

Jan 10, 2014 · Here we review four different types of LTA that can be distinguished on the basis of their chemical structure and describe recent advances in the biosynthesis pathway for type I LTA, d -alanylated polyglycerol-phosphate linked to di-glucosyl-diacylglycerol.

The cell wall component lipoteichoic acid (LTA) mimicked the impact of S. aureus elevating COX‐2/mPGES‐1 expression via NF‐κB and p38 MAPK signalling in MDM, while the impairment of 15 ...

Jul 6, 2019 · Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions.

Jan 9, 2019 · Assembly of the LTA GroP chain in S. aureus is catalyzed by a single enzyme LtaS, a transmembrane protein with a large extracytoplasmic domain that cleaves GroP from phosphatidylglycerol (PG) for elongation of GroP polymers …