PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.

Polyethylene glycol (PEG; / ˌpɒliˈɛθəlˌiːn ˈɡlaɪˌkɒl, - ˈɛθɪl -, - ˌkɔːl /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), …

Mar 7, 2014 · Polyethyleneglycol (PEG) coating of NPs (PEGylation) is the most efficient anti-opsonization strategy. Linear chains of PEG, grafted onto the NP surface, are able to create steric hindrance, resulting in a significant inhibition of protein …

PEGylation is the covalent and non-covalent attachment of activated polyethylene glycol (PEG) chain to various biomolecules. PEG is not toxic and nor immunogenic polymer. This technique is introduced as a strategy to eliminate some clinical disadvantages of biopharmaceuticals.

Oct 5, 2011 · Non-biofouling surfaces constitute one of the most important subjects in sensitively and selectively detecting biomolecular events. Poly (ethylene glycol) (PEG) chains tethered on substrate...

Our present study clarifies molecular details of PEG chain on protein surface and may be essential to the rational design, fabrication and clinical application of PEGylated proteins. PEGylation, conjugation of polyethylene glycol (PEG) to a therapeutic protein, is a successful approach to improve therapeutic potency of proteins [1], [2].

Feb 9, 2021 · The PEG conformation determines protein corona patterns and the abundance of distinct proteins in the corona. PEG chains with a brush conformation lead to increased adsorption of clusterin and decreased serum albumin in the corona.

Chain structure. The chemical structure of PEG and PEG-based derivatives plays an important role in regulating the hydrophilicity, biological responses, mechanical properties, protein repellency, degradation kinetics, and swelling of PEG-based hydrogels. 17 Among the more common modifications made is to attach biodegradable hydrophobic polymer ...

Mar 13, 2025 · In their structure, one end of the PEG chain is covalently attached to the hydrophobic anchor via the linker. This unique architecture combines PEG's advantageous properties—including biocompatibility, steric stabilization, and reduced immunogenicity—with the membrane-anchoring capability of lipids.

Aug 10, 2014 · Higher density grafting of shorter PEG chain lengths was found most favorable. This combination resulted into reduced nonspecific protein adsorption and higher uptake when compared to its lower density and longer chain length counterparts, respectively.