PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol–gels for drug delivery
Oct 28, 2016 · PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol–gels have been tested extensively in humans and have proven safety profiles and proven to be amendable to scale …
PEGylated polylactide (PLA) and poly (lactic-co-glycolic ... - Springer
Apr 22, 2019 · PEGylated polylactide (PLA) and poly (lactic-co-glycolic acid) (PLGA) copolymers are biodegradable polyesters, widely employed in the last decades for the design of drug …
Crystallization of supersaturated PEG-b-PLA for the production
Our findings indicate that the molecular weight of the solvent PEG and the target drug loading significantly influence the physicochemical properties of the resulting micelles, including …
Structural and thermodynamical investigation in triblock …
Mar 1, 2024 · A series of newly synthesized PLA-b-PEG-b-PLA triblock copolymers, prepared from a broad range of LA/PEG molar ratios, was studied using a combination of …
Recent advances in PEG–PLA block copolymer nanoparticles
As a research focus in recent years, polyethylene glycol–polylactic acid (PEG–PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of …
Facile synthesis of rapamycin-loaded PEG- b -PLA nanoparticles …
Mar 5, 2024 · In this work, a novel and facile method for the preparation of PEG-b-PLA NPs was achieved through a sequential two-step process, involving synthesis of PEG-b-PLA in DMF, …
Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel
May 1, 2000 · Copolymerization of the PEG-b-PLA macromer with acrylic acid leads to stronger gels with higher swelling ratios and degradation rates. This unique combination of properties is …
PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels for drug ... - PubMed
Oct 28, 2016 · In summary, PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels may safely enable pre-clinical evaluation and clinical translation of poorly water-soluble anticancer agents, …
Synthesis of PLA-b-PEG Multiblock Copolymers for Stealth Drug …
We propose here an efficient synthesis method for a polyester-polyethylene multiblock copolymer where the polyester (A) blocks alternate with polyethylene oxide (B) blocks to form a repetitive …
PEG-b-PLA Micelles and PLGA-b-PEG-b-PLGA Sol-Gels for Drug Delivery …
PEG-b-PLA micelles have enabled a novel 3-drug nanotherapeutic composed of paclitaxel, 17-AAG and rapamycin, termed Triolimus, enabling the investigation of combined anticancer …