Oligomycins are macrolides created by Streptomyces that are strong antibacterial agents but are often poisonous to other organisms, including humans. Oligomycins have use as antibiotics. However, in humans, they have limited or no clinical use due to their toxic effects on mitochondria and ATP synthase. [1]

Oligomycin, a therapeutically useless antibiotic produced by Streptomyces spp. Oligomycin inhibits the transport of protons across the stalk of the primary particle.

Oligomycin has been recognized as a potent inhibitor of the mitochondrial ATP synthase since 1958 when it was reported by Henry Lardy et al. (1).

They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and …

The oligomycin-sensitivity conferring protein (OSCP) of the mitochondrial FOF1 ATP synthase has long been recognized to be essential for the coupling of proton transport to ATP synthesis. Located on top of the catalytic F1 sector, it makes stable ...

Oligomycin A is an oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents.

Oligomycin has long been known as an inhibitor of mitochondrial ATP synthase, putatively binding the F (o) subunits 9 and 6 that contribute to proton channel function of the complex.

Apr 19, 2017 · The macrolide antibiotic oligomycin A was discovered in 1954. 1 It is a well-known inhibitor of the F O part of H + -ATP synthase and widely used for investigation of the mitochondrial F 1 F O...

Oligomycin blocks oxidative phosphorylation and the electron transport chain by inhibiting membrane bound mitochondrial ATP synthase (ATPase) and proton channel (pump, FO subunit) blocker.

Oligomycin B is an oligomycin with formula C45H72O12 that is oligomycin A in which the spirocyclic ring bearing the 2-hydroxypropyl substituent has been substituted by an oxo group at the carbon which is directly attached to the spirocentre. It is a nonselective inhibitor of the mitochondrial F1F0 ATP synthase.