Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium -dependent zinc -containing endopeptidases; [1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. [2]

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis.

Membrane-type metalloproteinases (MT-MMP; Appendix A, Table A5) contain a furin-like pro-protein convertase recognition site (RX[R/K]R) in their pro-domain C-terminal [1,8,17,18], allowing pro-enzyme activation by proteolytic removal of this domain.

Typical structure of MMPs consists of several distinct domains. MMP family can be divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type MMPs, and other non-classified MMPs.

In this review, we will give an overview of 23 members of the human MMP family and describe functions, linkages to disease and structural and mechanistic features. MMPs can be grouped into soluble (including matrilysins) and membrane-anchored species.

Jan 15, 2025 · Matrix metalloproteinases (MMPs) are endopeptidases that depend on calcium and zinc and are essential in numerous biological processes. The first known MMP was an interstitial collagenase (MMP1), which was identified in …

Matrix metalloproteinases (MMPs, aka matrixins) are zinc-dependent endopeptidases that are members of the metzincin-superfamily of enzymes. The first MMP (MMP-1) was discovered in tadpoles during embryogenesis (1), hinting at the prominent role …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent protease enzymes required for normal tissue remodeling and mediating collagen metabolism and extracellular matrix (ECM) homeostasis. 107 Four common classes of MMPs have been identified: gelatinases (MMP-2 and MMP-9), collagenases (MMP-1 and MMP-8), stromelysin (MMP-3), and ...

3 days ago · MMP structure and types of activation. Membrane-type matrix metalloproteinases (MT-MMPs); tissue inhibitors of MMPs (TIMPs); fibronectin (FN). Figure 2. (A) MMP in atherosclerosis: MMPs contribute to plaque formation and rupture by degrading the extracellular matrix in blood vessels, promoting inflammation and endothelial dysfunction. Cytokine ...

The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are proteases capable of remodeling the extracellular matrix.