In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and the clinical manifestations of this group of leukemias.

Nov 5, 2020 · Background: Acute myeloid leukemias with KMT2A (formerly known as MLL-1) fusion genes (MLL-AML) and those with NPM1 mutations (NPM1-AML) are distinct subtypes as defined by the WHO classification.

We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a reciprocal translocation involving the 11q23 locus (MLL) who were treated at Memorial Sloan Kettering Cancer Center (MSK).

Oct 1, 2003 · Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification.

Acute myeloid leukemia (AML) results from clonal expansion of transformed hematopoietic stem cells (HSCs) through the acquisition of genetic abnormalities including chromosomal rearrangements and multiple gene mutations whereby HSCs are conferred a proliferative and survival advantage and impaired hematopoietic differentiation.

Jan 24, 2013 · AML with MLL gene alterations (11q23/ MLL+ AML) represents 3-4% of all AML cases and occurs most frequently in young people with “ de novo” AML (5-7%) and in treatment-induced AML (t-AML) patients (10-15%).

1 day ago · For primary murine MLL-AF9/Flt3 ITD/+ /Cas9 AML experiments related to Fig. 4g,h, 6–10-week-old NSG male mice were injected with 10 6 primary murine AML cells by intravenous injection from the ...

Mar 25, 2025 · Background Acute myeloid leukemia (AML) is the most common type of acute leukemia, accounting for 20% of cases in children and adolescents. Genome-wide studies have identified genes that are commonly mutated in AML, including many epigenetic regulators involved in either DNA methylation (DNMT3A, TET2, IDH1/2) or histone post-translational modifications (ASXL1, EZH2, MLL1). Several cell lines ...

Sep 12, 2018 · Among major human acute myeloid leukemias (AMLs), MLL -rearranged AML (MLL -AML) is characteristic of poor prognosis due to refractoriness to chemotherapy and shorter period to relapse [1,...

Objective: MLL gene is involved in more than 80 known genetic fusions in acute leukemia. To study the relevance of MLL partner gene and selected gene's expression, in this work, we have studied a cohort of 20 MLL-rearranged acute myeloid leukemia (AML).