Feb 10, 2016 · The streptococcal M protein is now probably one of the best-defined molecules among the Gram-positive bacterial virulence determinants. Its structure, function, immunochemistry, and method of antigenic variation are unique among known virulence molecules, and may serve as a model for certain microbial systems (Fischetti, 1989).

M protein is strongly anti-phagocytic and is the major virulence factor for group A streptococci (Streptococcus pyogenes). It binds to serum factor H , destroying C3-convertase and preventing opsonization by C3b .

The M protein coats group A streptococci (GAS) and acts as the primary antigen and determinant of type-specific immunity. M is essential for GAS virulence, providing antiphagocytic functions critical to survival in human tissues and fluids.

Jan 17, 2025 · Explore the role of M protein in Streptococcus, focusing on its structure, genetic variability, and strategies for immune evasion.

Sep 6, 2010 · Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease.

Sep 6, 2010 · M proteins are streptococcal surface proteins that probably represent one of the best-known virulence determinants of this pathogen. This review will focus on the M proteins and their role as virulence factors in streptococcal infections.

Jun 1, 2010 · Interaction of the M-protein of group A Streptococcus (GAS) with its numerous host binding partners might assist the bacteria in evading host immune responses.

Jun 10, 2020 · Interaction of the M-protein of group A Streptococcus (GAS) with its numerous host binding partners might assist the bacteria in evading host immune responses.

M protein is a major virulence determinant for the group A streptococcus by virtue of its ability to allow the organism to resist phagocytosis. Common in eucaryotes, the fibrillar coiled-coil design for the M molecule may prove to be a common motif for surface proteins in …

Apr 8, 2024 · emm encodes the M virulence protein found on the cell surface. This hypervariable sequence is downstream of forward primer sequence, allowing for direct sequencing. CDC uses a de novo assembly approach for whole-genome sequence-based emm subtype determination.