We recently developed an in vitro model of human inner ear organogenesis using pluripotent stem cells in a 3D culture, fostering the growth of a sensorineural circuit, including hair cells and …

Ear modeling can significantly improve sound signal processing and the design of hearing devices. Ear models based on mechanics and neu-ral phenomenology of the inner ear …

The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely, …

Nov 11, 2022 · Here, we review how pluripotent stem cells have been used to produce two-dimensional and three-dimensional otic cultures, the strengths and limitations of these new …

Jan 16, 2024 · Advances in stem cell technology and organoid culture offer unique opportunities for modeling inner ear diseases and developing personalized therapies for hearing loss. Here, …

Dec 5, 2023 · Herein, we describe the developmental history and progress of the tissue-specific progenitor cell/PSC-derived inner ear organoids. To date, inner ear organoids have been …

Mar 11, 2024 · The three-dimensionally printed inner-ear model is highly simulated and provides a valuable visual tool for studying inner-ear anatomy and clinical teaching, benefiting otologists.

Mar 19, 2015 · The developmental patterning mechanisms that underlie formation of the inner ear from the otic placode are varied and complex, involving the reiterative use of familiar signalling …

The OtoBiomechanics Group at Stanford is developing three-dimensional and multiscale bio-computational models of the middle ear and the inner ear and their applications to …

In vitro models of the inner ear, like the organoid system, could aid in identifying new regenerative drugs and gene therapies. Here, we provide a perspective on the status of in vitro inner ear …