Purified from fresh frozen human plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. No Plasmin activity is detected using the chromogenic substrate S-2251. Plasminogen is activated to the serine protease plasmin via urokinase, streptokinase or tissue plasminogen activator.

Native glu-plasminogen is prepared from fresh frozen human plasma by a modification of the procedure of Castellino (3), utilizing gel filtration and affinity chromatography. The two carbohydrate variants of glu-plasminogen (CHOI and CHOII) are isolated by gradient elution from lysine-Sepharose using the lysine analog, -aminocaproic acid (3).

Mar 22, 2018 · Plasminogen replacement therapy should provide an effective treatment of the manifestations of congenital plasminogen deficiency. An open-label phase 2/3 study of human Glu-plasminogen administered IV at 6.6 mg/kg every 2 to 4 days in 15 patients with congenital plasminogen deficiency is ongoing.

Native glu-plasminogen is prepared from fresh frozen human plasma by a modification of the procedure of Castellino, utilizing gel filtration and affinity chromatography. The two carbohydrate variants of glu-plasminogen (CHOI and CHOII) are isolated by gradient elution from lysine-Sepharose using the lysine analog, e-aminocaproic acid.

RP-43078 contains native human glu-Plasminogen protein. RP-43078 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin.

Native Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein zymogen, which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 µM.

Plasminogen is synthesized mainly by the liver but also the eosinophils, the kidney and the cornea. It exists in 2 molecular forms: glu-plasminogen (native form) and lys-plasminogen (more active form). The main pathways for activating plasminogen to plasmin involve t-PA and u-PA.

Coagulation Protein, Human glu-Plasminogen, 1 milligram, Purifed from plasma, Zymogen, MW=88,000, Structure: single chain, 24 intra chain disulfide bridges, 5 kringle regions, Research use only, 50% (v/v) glycerol/water, Store at -20 Celsius

Our studies have shown that native Glu-Plg isolated from normal human plasma from various sources either fresh or frozen, prepared either in-house or commercially, contains chemically linked oxPtdPCs.

Human plasminogen is a beta-globulin (2% carbohydrate, molecular weight 90 KD), which in its native form has NH2-terminal glutamic acid (Glu-plasminogen) whose primary structure is known (31, 37, 38).