Human placental growth hormone (PGH), encoded by the growth hormone (GH) variant gene on chromosome 17, is expressed in the syncytiotrophoblast and extravillous cytotrophoblast layers of the human placenta. Its maternal serum levels increase throughout pregnancy, and gradually replaces the pulsatile secreted pituitary GH.

Jun 25, 1988 · We have sought direct evidence for the in vivo expression of the human growth hormone-variant (hGH-V) gene by screening a placental cDNA library with a hGH-V-specific oligonucleotide. Nine independent hGH-V cDNA clones were isolated and analyzed, and three distinct species were detected.

The hGHv complex is shown in salmon (hormone) and blue (R1/R2), and the WT hGH complex is shown in green (hormone) and yellow (R1/R2). The structures were superimposed by using the β-sheets in both the N- and C-terminal domains of the hGH receptor (hGHR).

Find out what is the full meaning of HGHV on Abbreviations.com! 'High Growth High Value' is one option -- get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource.

Nov 5, 1998 · In all, our results indicate that the hGH-V gene is highly conserved in the normal population. The human growth hormone variant (hGH-V) gene is a member of the GH gene family, expressed by the syncytiotrophoblast.

The human GH-variant (hGH-V) gene, a member of the GH-PRL gene family, is expressed by the placenta during the second and third trimesters of gestation. The secreted hGH-V protein differs from pituitary GH (hGH-N) by only 13 amino acids.

Using young male Wistar rats fed either chow or a high-fat (HF) diet for 4 wk postweaning, we investigated the effect of 7 days treatment with either 22-kDa hGH-N, 20-kDa hGH-V (5 ug x g (-1) x day (-1) sc), or vehicle on body composition and endocrine and metabolic profiles.

In this study recombinant human growth hormone (rhGH; Genotropin ®), expressed in E. coli K12, was structurally analyzed by two-dimensional gel electrophoresis and MALDI-TOF-TOF, LC-MS and LC-MS/ MS sequencing of the resolved peptides.

Extensive functional analyses of the hormone-receptor bind-ing interfaces of human growth hormone (hGH)1 and human prolactin, using site-directed alanine-scanning mutagenesis, have indicated that molecular specificity and binding affinity of these molecules are driven by a relatively few key residues (4–6).

Sep 8, 2020 · A new study by List et al suggests that the 20-kilodalton (kDa) variant of placental hGH (hGH-V) may retain the growth-promoting benefits of GH but with a beneficial reduction in diabetogenic activity (1).