In molecular biology, the guanylate-binding proteins family is a family of GTPases that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma (Interferon-inducible GTPase) are key to the protective immunity against microbial and viral pathogens.

Oct 1, 2023 · Guanylate-binding proteins (GBPs) have newly identified functions, including pattern-recognition capabilities and pathogen-selective antimicrobial activities against bacteria, viruses, and parasites.

Jul 29, 2022 · Here, we show that guanylate-binding proteins (GBPs) mediate pathogen-selective inflammasome activation. We show that mouse GBP1 and GBP3 are specifically required for inflammasome...

Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene. [5] [6] GBP2 is a gene related to the superfamily of large GTPases which can be induced mainly by interferon gamma. [7]

In this review, we outline emerging evidence that highlights the potential role of IFN-inducible GTPases (ISGs), and particularly the guanylate-binding protein (GBP) family, in the context of autoimmunity.

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell types, these IFN-induced GTPases assemble into large nanomachines that execute distinct host defense activities against a wide variety of microbial pathogens.

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics.

Oct 1, 2023 · One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma.

Oct 3, 2017 · Guanylate-binding proteins (GBPs) are a group interferon-inducible GTPases within the constellation of the dynamin GTPase superfamily. These proteins restrict the replication of intracellular pathogens in both immune and non-immune cells.

Aug 9, 2023 · Guanylate-binding proteins (GBPs) have newly identified functions, including pattern-recognition capabilities and pathogen-selective antimicrobial activities against bacteria, viruses, and parasites.