Mar 30, 2025 · FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOS include Histiocytoid Hemangioma and Congenital Generalized Lipodystrophy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

The leucine zipper is responsible for dimerization of the Jun and Fos protein subunits. This structural motif twists two alpha helical protein domains into a “ coiled coil,” characterized by a periodicity of 3.5 residues per turn and repetitive leucines appearing at every seventh position of the polypeptide chain.

Bioinformatic identification of c-Jun/c-Fos binding motifs in the EBV genome. Deep sequencing data were analyzed with the SISSRs algorithms for putative stretches of DNA, which c-Jun/c-Fos binds.

Fos and Jun oncoproteins form a complex that regulates transcription from promoters containing AP-1 binding sites. These two proteins, like other transcriptional activators, are likely to stimulate transcription through direct and/or in direct ...

Aug 6, 2003 · All Fos family members (Fos proteins) contain bZIP motifs, which include leucine zipper regions responsible for heterodimerization with Jun, and basic regions specifying binding to the 12- O...

The term “Fos/Jun” is used for a number of structurally and functionally related members of the Fos and Jun protein families of transcription factors, collectively described as activating protein-1 (AP-1).

In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial–mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell.

Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2) dimerise with Jun proteins to form the AP-1 transcription factor complex.

Jun-AP1 (bZIP)/K562-cJun-ChIP-Seq (GSE31477)/HomerFOS::JUNB/MA1134.1/Jaspar

The osteoclast differentiation factor Rankl (also known as TRANCE, ODF and OPGL; refs 8–11) induces transcription of Fosl1 in a c-Fos–dependent manner, thereby establishing a link between Rank ...