Jun 23, 2020 · By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of...

Oct 21, 2005 · In the case of c-Fos, the activation of ERK leads to an increased expression of c-fos mRNA. In turn, we have recently shown that ERK phosphorylates multiple residues within the carboxylterminal transactivation domain (TAD) of c-Fos, thus resulting in its increased transcriptional activity.

In the case of c-Fos, the activation of ERK leads to an increased expression of c-fos mRNA. In turn, we have recently shown that ERK phosphorylates multiple residues within the carboxylterminal transactivation domain (TAD) of c-Fos, thus resulting in its increased transcriptional activity.

Oct 21, 2005 · In the case of c-Fos, the activation of ERK leads to an increased expression of c- fos mRNA. In turn, we have recently shown that ERK phosphorylates multiple residues within the carboxylterminal transactivation domain (TAD) of c-Fos, thus resulting in its increased transcriptional activity.

Aug 1, 2012 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many ERK1/2 substrates possess a D-docking site, an F-docking site, or both.

Extracellular signal-regulated kinases 1/2 (ERK) belong to the family of mitogen-activated protein kinases (MAPK) that operate within signaling cascades that transmit extracellular signals to their intracellular targets.

Mar 13, 2000 · We find here that the FAP1 site contributes strongly to phorbol ester (TPA) and Erk MAP kinase activation of the c- fos enhancer and that both the p62 TCF and FAP1 sites are required for...

Jan 17, 2024 · We determined that phosphorylated c-Fos promoted colon cancer cells resistance to 5-FU by facilitating the cancer stemness. Mechanically, 5-FU treatment induced autolysosome-dependent degradation...

Our findings suggest that c-Fos repre-sents a novel target for the isomerizing activity of Pin1 and support a role for Pin1 in the mechanism by which c-Jun and c-Fos can cooperate to regulate AP-1-dependent gene transcription upon phosphorylation by …

Jul 25, 2006 · The recent work from Nishida and colleagues has now identified another important molecular event that is at least in part directly controlled by c-Fos and other AP-1 components in response to sustained ERK signalling — the downregulation of a …