Ultrasound-responsive low-dose doxorubicin liposomes trigger ...
Jun 30, 2023 · Chemotherapeutics such as doxorubicin can induce immunogenic cell death (ICD) of tumor cells 1, 2, 3. The key features of chemotherapeutics-induced ICD include CRT …
Synergistic effect of tumor chemo-immunotherapy induced by ... - Nature
Aug 6, 2021 · Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further …
Cancer-activated doxorubicin prodrug nanoparticles induce preferential ...
May 1, 2021 · The effective chemotherapeutic drug, doxorubicin (DOX), elicits immunogenic cell death (ICD) and additional anticancer immune responses during chemotherapy. However, it …
Co-delivery of IOX1 and doxorubicin for antibody-independent …
Apr 23, 2021 · Here the authors report that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces the expression of PD-L1 in cancer cells and enhances …
Co-delivery of doxorubicin and STING agonist cGAMP for …
Apr 10, 2024 · Building upon these findings, we constructed a doxorubicin (DOX) and cGAMP co-delivery system (DOX/cGAMP@NPs) for melanoma and triple-negative breast cancer (TNBC) …
Double enhancement of immunogenic cell death and antigen presentation ...
Aug 1, 2021 · It is speculated that DOX@PM could cause a higher degree of ICD, release more TAAs and induce a stronger immune response. Moreover, XCL-1 enhanced the antigen cross …
Doxorubicin-induced Immunogenic Cell Death Impairs Tumor
The ICD induction by DOX on 4T1 was assessed by flow cytometry and image analysis. This immunization process was performed three times and after the last administration, the …
Immunogenic Cell Death Activates the Tumor Immune …
Recent studies reveal that some chemotherapeutics including doxorubicin (DOX), paclitaxel (PTX), and oxaliplatin (OXA) could kill tumor cells via the ICD pathway, which could activate …
Advances in Immunogenic Cell Death for Cancer Immunotherapy
May 16, 2023 · The concept of immunogenic cell death (ICD) was originally coined by Kroemer in 2005, demonstrating that tumor cells treated with doxorubicin (DOX) activated the host …
Sequentially pH-Responsive Drug-Delivery Nanosystem for Tumor ...
Sep 22, 2021 · As a burgeoning approach, immunotherapy has shifted the paradigm of traditional chemotherapy and opened up new prospects for cancer treatment. Here, a sequentially pH …