Apr 1, 2023 · During plant stress and developmental response, the burst of reactive oxygen, nitrogen, and sulfur species (ROS/RNS/RSS) can trigger the oxidation of Cys thiols by direct reaction with TF or in an enzymatic-dependent way, such as redox transducer and transferase.

Jun 10, 2014 · We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys …

The oxidative interface consists mainly of the redox regulation of redox-reactive cysteine (Cys) residues on proteins by ROS. Oxidation of these residues forms reactive sulfenic acid (−SOH) that can form disulfide bonds with nearby cysteines (−S–S−) or undergo further oxidation to sulfinic (−SO 2 H) or sulfonic (−SO 3 H) acid; if ...

We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys residues of redox-sensitive proteins.

Jan 18, 2013 · During the last 2 decades, reactive oxygen species/reactive nitrogen species (ROS/RNS) have been found to function as important physiological regulators of intracellular signaling pathways. 1, 2 The specific effects of ROS/RNS are modulated, in part, through the covalent modification of specific cysteine (Cys) residues found within redox-sensiti...

Apr 20, 2018 · Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated...

Nov 21, 2016 · Therapeutic depletion of extracellular L-Cys and CSSC selectively targets cancers cells causing potent growth arrest and killing, increased levels of ROS, decreased levels of GSH, and...

Sep 29, 2011 · Cysteine residues (Cys) in proteins are prominent targets for protein oxidation, as they easily react with H 2 O 2 and free radicals. Oxidation of Cys by H 2 O 2 involves nucleophilic attack of the cysteinyl thiol group on the electrophilic center of H 2 O 2.

Nov 27, 2020 · Cys-based redox regulation was long regarded a major adjustment mechanism of photosynthesis and metabolism in plants, but in the recent years, its scope has broadened to most fundamental processes of plant life.

Jan 1, 2024 · Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.