The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

Aug 30, 2021 · C-terminus is one of the terminal groups of two ends of the peptide chain. The end of the polypeptide with a free Carboxyl group (-COOH) is known as C-terminus.

Mar 19, 2025 · The two ends of a polypeptide chain—the N-terminus and C-terminus—are crucial for stability, localization, and interactions. Understanding these termini is key to studying protein behavior in cells and designing targeted therapeutics.

Mar 21, 2025 · The C terminus, defined by a free carboxyl (-COOH) group, represents the final residue in a polypeptide chain. Its structural characteristics, shaped by the amino acid sequence, influence protein conformation and biochemical properties.

Nov 16, 2022 · The main difference between N-terminus and C-terminus is that N-terminus is the end of the peptide with a free amine group (-NH2), whereas C-terminus is the end of the peptide with a free carboxyl group (-COOH).

The C-terminus, also known as the carboxyl-terminus, COOH-terminus, or C-terminal end, concludes the polypeptide chain. It is distinguished by a free carboxyl group (-COOH) and marks the final amino acid in the sequence.

Explore N-terminus and C-terminus in proteins with Creative Proteomics's comprehensive guide, covering principles, methods, and detailed analysis.

The C terminus (residues 96–140) contains 15 acidic amino acids (10 Glu and 5 Asp residues) and the only 5 Pro residues of the protein (P108, P117, P120, P128, and P138). By means of its low hydrophobicity and high net charge, the C terminus is responsible for the intrinsically disordered nature of α-SYN.

The c-terminus refers to the end of a polypeptide or protein chain that has a free carboxyl group (-COOH). This structural feature is crucial in determining the overall shape and function of the protein, as it influences interactions with other molecules and the folding of the protein chain.

The C-terminus, or carboxy-terminus, refers to the end of a polypeptide or protein chain where the carbon atom of the carboxyl (COOH) group is located. It is one of the defining structural features of peptides and proteins, and its properties play a crucial role in their function and behavior.