In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and the clinical manifestations of this group of leukemias.

Nov 5, 2024 · Gene expression analysis showed that MLL-AF9-or MLL-ENL-driven leukemogenesis in mice recapitulated human MLL-r B-ALL disease very well. Our mouse models highlighted applicable strategies to understand molecular mechanisms and test/develop therapeutic agents for human MLL- r B-ALL.

Dec 2, 2022 · Multivariate analysis showed that T-cell, white blood cell counts (WBC) ≥ 50 × 10 9 /L, MLL-AF4, and D15 minimal residual disease (MRD) positive were independent risk factors affecting the prognosis of MLL-r positive children.

Nov 15, 2022 · Introduction: Acute leukemia with translocation t (10;11) (p12-13;q14-21) results in generation of the PICALM:MLLT10 fusion gene, and is distinct from t (10;11) (p11-13;q23) which gives rise to KMT2A (formerly MLL) gene rearrangement.

Here, we revisit the main advantages and pitfalls for current mouse models for MLL-AF4, MLL-ENL, and MLL-AF9, the commonest MLL translocations found in human acute lymphoid and myeloid acute leukemia.

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and ...

In this review, we discuss MLL-r-ALL focusing on clinical presentation, risk stratification, drug resistance, and treatment strategies, including potential novel therapeutic targets. Keywords: Acute lymphoblastic leukemia; KMT2A; MLL; Resistance.

Jan 24, 2013 · Multiplexed reverse transcription PCR (MRT-PCR) Anderson et al., 2001, developed this quick and accurate method to identify the six most common MLL gene translocations: MLL/AF4 (acute lymphoblastic leukemia), MLL/AF6, MLL/AF9, MLL/AF10, MLL/ENL, and MLL/ELL. MRT-PCR is based on two individual steps.

Nov 13, 2019 · We analyzed the pts characteristics at baseline and evaluated remission rates, overall survival (OS) and relapse-free survival (RFS). The survival curves were estimated using the Kaplan-Meier method and differences between groups were evaluated with the log-rank test.

Feb 9, 2017 · In this review, we will discuss the normal biological roles of MLL1 and its fusion partners, how these roles are hypothesized to be dysregulated in the context of MLL1 rearrangements, and the clinical manifestations of this group of leukemias.