In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]).

Dec 21, 2001 · Area under the curve (AUC) is expressed in units of μg · h/mL (μg × h/mL) AUC total area under the plasma drug concentration–time curve (from time zero to infinity).

In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

Nov 1, 2024 · AUC in pharmacokinetics represents the actual body exposure to the drug after the administration of a dose of the drug. Generally, area under the curve is reported in amount/ volume x time. AUC in pharmacokinetics units is expressed in mg x h / L or μg / ml x hrs or µg hr/mL or mg x L-1 x hr or g/100 mL x hr or g hr/mL [1,2]

The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the …

Version 1.2, updated 8.18.2020. AUC exposure targets using the harmonized units of mg × h are typically expressed as cumula ve AUC. Conceptually, Css is measured for an individual dose or an average over me, thus a cumula ve exposure cannot be directly measured in Css. Sea le Cancer Care Alliance, Pharmacokine cs Laboratory.

Oct 14, 2012 · Area Under Curve (AUC) has been frequently used as the endpoint measure in clinical trials. We use AUC commonly in clinical pharmacology - Area under the time concentration curve or in diagnostic research – Area Under the ROC curve. The use of AUC is much more broader than what we think.

The area under the concentration vs. time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. This page summarizes the calculations and terminology that may be encountered.

The AUC is of particular use in estimating bioavailability of drugs, and in estimating total clearance of drugs (ClT). Following single intravenous doses, AUC = D/ClT, for single compartment systems obeying first-order elimination kinetics; alternatively, AUC = C0/kel.

Apr 2, 2025 · In non-compartmental analysis (NCA), the area under the concentration-time curve (AUC) is a key parameter used to quantify total drug exposure over time. Along with Cmax, AUC is a fundamental parameter for assessing systemic drug exposure and is commonly used for comparisons in pharmacokinetic studies.