Oct 3, 2017 · AUC = target area under the concentration versus time curve in mg/mL•min. GFR was measured by 51Cr-EDTA clearance. Estimations of GFR are frequently used in clinical practice, however, several important points should be reviewed (see below).

This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus...

This Carboplatin AUC calculator determines the total dosage in mg based on the estimated creatinine clearance and target AUC plus the ideal body weight.

The Calvert formula(1) established a dosage formula to achieve a target area under the curve (AUC) plasma concentration of carboplatin based on the patient’s GFR. The Calvert formula is: Carboplatin dose (mg) = target AUC x (GFR + 25)

Target carboplatin AUC values of 5 and 7 mg/ml/min are recommended. This carboplatin AUC calculator uses the above method to find your carboplatin dose. We want to find the GFR of a 50-year-old man who weighs 78 kilograms and has a serum creatinine level of 1.2 mg/dL.

The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure.

Jan 29, 2018 · Compared with an AUC of 5 or 6, the actual clinical application of AUC was generally insufficient for Chinese populations; fortunately, therapeutic efficacy remained equal. We found that AUC <4 was as adequate as AUC ≥4 in pemetrexed plus carboplatin regimen as first‐line treatment for them.

In this real-world analysis of Carboplatin AUC 5 vs 6, there appears to be no clinically significant difference in survival and toxicity outcomes between the two dosing strategies in patients with advanced NSCLC. Carboplatin remains the backbone for combination therapy of patients with many cancers including NSCLC.

Mar 1, 2021 · Doses of AUC equal to 5 or 6 are commonly administered in NSCLC based on sentinel studies leading to the approval of carboplatin-based regimens. Therefore, we sought to evaluate if there is a difference in efficacy and/or toxicity between the two doses.

Aug 2, 2024 · The AUC ratio is a measure used in pharmacokinetics to describe the relationship between the area under the curve (AUC) and the dose of a drug. The AUC represents the total exposure of the body to the drug over time, while the dose is the amount of the drug administered.