PT-112, the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, leading to recruitment of tumour-infiltrating lymphocytes. PT-112 also associates with bone (osteotropism), likely driven by its pyrophosphate moiety.

PT-112 is a novel platinum-pyrophosphate conjugate under clinical development for cancer therapy. PT-112 mediates cytostatic and cytotoxic effects against a variety of human and mouse cancer cell lines in vitro.

Feb 21, 2023 · Preclinical studies have shown the robust induction of immunogenic cell death by PT-112, leading to an anti-cancer adaptive immune response. Biodistribution experiments in mice showed PT-112’s partial bone affinity.

Nov 5, 2020 · In phase I studies in solid tumors, PT-112 demonstrated safety and efficacy as single agent and in combination with PD-L1 checkpoint inhibitor avelumab, crossing a range of dose levels (DL) and tumor types, including in heavily pre-treated patients (pts) non-responsive to immunotherapy and refractory to other modalities.

May 31, 2023 · PT-112, a novel inducer of immunogenic cell death, has demonstrated safety and efficacy in phase I trials. We present results of an unplanned interim analysis of a phase 2, NIH IRB-approved clinical trial to evaluate the clinical activity, tolerability, and correlative immunology of PT-112 in TETs (NCT05104736).

Background: PT-112, a novel platinum pyrophosphate agent under development in solid tumors and hematological malignancies, is a potent inducer of damage associated molecular patterns (DAMPs) characteristic of ICD. It also affects G1/S cell cycle transition independent of DNA damage or repair pathways.

Feb 19, 2020 · The most common PT-112 TRAEs were thrombocytopenia (70%, grade (Gr) ≤3) and fatigue (40%, Gr ≤2) with mono-Tx; nausea (50%, Gr ≤2) and fatigue (39%, Gr ≤2) with PAVE.

Background: PT-112 is a novel pyrophosphate-platinum conjugate, with clinical activity in advanced, pre-treated solid tumors including lung cancers, thymoma and castration resistant prostate cancer (CRPC).

Dec 7, 2017 · Introduction: PT-112 is a first-in-class platinum-pyrophosphate agent under advanced Phase I development in solid tumors. PT-112 was rationally designed to circumvent the toxicity and mechanisms of resistance associated with conventional chemotherapy.

PT-112 is a novel pyrophosphate–platinum conjugate, with clinical activity reported in advanced pretreated solid tumors. While PT-112 has been shown to induce robust immunogenic cell death (ICD) in vivo but only minimally bind DNA, the molecular mechanism underlying PT-112 target disruption in cancer cells is still under elucidation.