England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,

England lose Jamie George for Six Nations opener as injuries mount before Ireland clash - Alex Mitchell is also doubtful for Dublin trip, with Alex Coles, Jack van Poortvliet and Alex Dombrandt all ru

Jamie George, replaced as England captain by Maro Itoje last week, has been ruled out of their Six Nations opener against Ireland, with scrumhalf Alex Mitchell also a doubt after the squad was hit by a raft of injuries.

Vice-captain Jamie George heads England withdrawals for Six Nations opener - Influential scrum-half Alex Mitchell is a doubt for the opener against Ireland on February 1.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.