Ubiquitin ligases are enzymes involved in the ligation step of ubiquitylation. Ubiquitin ligases bind the substrate protein and catalyse the transfer of ubiquitin from the cysteine of ubiquitin ...

Targeted Oncology provides news, videos, and reviews on the rapidly evolving world of targeted therapies and immunotherapy ...

Recently, the research teams led by Professors Yu Tao and Feng Yugong from The Affiliated Hospital of Qingdao University ...

Shanghai Helioson Pharmaceutical Co. Ltd. has synthesized molecular glue degraders comprising an E3 ubiquitin ligase coupled to a eukaryotic peptide chain release factor GTP-binding subunit ERF3A ...

Ubiquitin is a small, covalent modifier that forms a poly-ubiquitin chain on protein, which becomes a degradation signal attacked by the 26S proteasome 11,12,13. The poly-ubiquitin chain is ...

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, ...

Bipolar disorder is characterized by extreme mood swings, bouts of mania or hypomania, and episodes of depression. It is a highly heritable ...

Kymera Therapeutics Inc. has described proteolysis targeting chimera (PROTACs) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to a signal transducer and activator of ...

As Inc functions as an adapter protein for Cullin-3 ubiquitin ligase, and Cullin-3 mutations have been associated with autism spectrum disorder, the findings provide a potential mechanistic ...

We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...