WILMINGTON, DE — NiKang Therapeutics® Inc. has achieved a pivotal step in the development of its first-in-class CDK2 degrader ...

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to ...

In cell experiments, muscle precursor cells (C2C12) exhibited excellent viability and proliferation within the hydrogel matrix, demonstrating potential applications in tissue engineering and ...

Treatment of C2C12 myotubes with Cdk5 antisense oligonucleotides ... Antibodies specific for p35 (c-19), Cdk2 (M2), cyclin A (H-432), Cdk5 (c-8 and DC-17), ErbB2 (c-18) and ErbB3 (c-17) were ...

resulting in a shift from Treg to an effector-like T cell phenotype- -Preclinical data was presented on its CDK2 selective molecular glue degrader, which exhibited superior selectivity over ...