Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...

A study by Oregon Health & Science University researchers has uncovered a new way proteins can be changed inside cells. This ...

Such modifications include ubiquitination and covalent attachment of ubiquitin-like molecules (e.g., SUMO or small ... was used as a model system (Riquelme et al., 2006, 2 separate publications).

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

That weapon is Velcade (bortezomib), a drug that inhibits an intracellular protein-disposal system known as ubiquitin-mediated proteolysis (UMP). Made by Cambridge, Mass.-based Millennium ...

are certainly of interest but do not yet provide an informative tool useful in the screening of inhibitors that may interfere with the multiple steps (ubiquitin tagging, unfolding, and proteolysis ...

Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...