The buildup of uric acid in your joints can cause swollen growths under your skin known as tophi. If left untreated, tophi can lead to loss of motion in your joints and other complications.

If crystal removal from joints and tissues leads to the disappearance of acute attacks and tophi – which may be considered as the cure of the disease – we should aim to achieve it earlier ...

She also had numerous small subcutaneous tophi in her hands. The patient was intolerant to allopurinol and had mild renal insufficiency attributed to uric-acid nephrolithiasis and interstitial ...