Efforts to design improved derivatives of the SIRT1 inhibitor suramin, a symmetric polyanionic naphthylurea, have led to the discovery of highly potent and selective inhibitors of SIRT1 and SIRT2 ...

The controversy over Sirtris drugs reached a tipping point in January with a publication by Pfizer researchers led by Kay Ahn showing that resveratrol activates SIRT1 only when linked to a ...