Thus, it is RNA pol II that transcribes the messenger RNAs, which serve as the templates for production of protein molecules. The first step in transcription is initiation, when the RNA pol binds ...

RNA levels of the remaining 5,000–6,000 standard yeast genes vary over a wide range, but together represent ∼ 50% of all Pol II transcription 13, which gives an average value for a standard ...

2025. RNA polymerase II at histone genes predicts outcome in human cancer. Science. Jan 2;387(6735):737-743. Hannah Lewis is a postdoctoral research fellow with Jim Boonyaratanakornkit’s group in the ...

The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator, and RNA polymerase II (pol II). As a central integrator of both general and TF-specific regulatory signals, Mediator plays a ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...