Scientists have tapped into the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair (NER). This research reveals how damaged strands of DNA are repaired ...

PInC plays a key role in regulating DNA repair processes in the latter stages of the NER pathway. Decoding NER's sophisticated sequence of events and the role of PInC in the pathway could provide ...

The native structure of genomic DNA can be damaged in many ways, both by external agents and from within the cell as a consequence of normal metabolism In an effort to maintain their genomic ...

Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER) by generating lethal DNA breaks during by transcription ...

This method is often referred to as "light repair," because it is dependent on the presence of light energy. (In comparison, NER and most other repair mechanisms are frequently referred to as ...