The goal of the mitotic cell cycle is to replicate the genome ... For some proteins (for example, cyclins), protein synthesis and/or degradation are repeatedly switched between different rates ...

The reason for this lies in the cyclins' cooperation with a kinase ... Positively charged specificity site in cyclin B1 is essential for mitotic fidelity, Nature Communications (2025).

In the past, this labs study of G1 cyclins and the Kip family of cdk inhibitors contributed ... themselves in a state in which it might be years before they re-enter the mitotic cell cycle. Work in ...