It is conjectured that drospirenone, taken alone or concomitantly with spironolactone, may be associated with an increased risk of hyperkalemia. Methods: A retrospective cohort study was conducted ...

The drug can sometimes cause life-threatening hyperkalemia, however, when used in combination with angiotensin-converting enzyme (ACE) inhibitors (which are also indicated for heart failure).

Hyperkalemia is a potentially serious condition that may be associated with numerous pathophysiological conditions. Clinically significant hyperkalemia reduces membrane excitability and disturbs ...