The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

Onchilles Pharma Presents New Data at AACR 2025 Highlighting N17350, a Next-Generation Cytotoxic Therapeutic Leveraging the ...

Unlike traditional chemotherapies, which indiscriminately damage both cancer and healthy immune cells, N17350 leverages elevated levels of histone H1 isoforms found in cancer cells to selectively ...