We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...
However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.
The Constitutive Photomorphogenesis 1 (COP1)protein is an ubiquitin E3 ligase, which targets many proteins for degradation. Until now, it has been most extensively studied for its role in repression ...
Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. My research interests ...
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TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancerOvarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, ...
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...
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Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzymeResearchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a critical type of protein ... a group of enzymes called E3 ubiquitin ligases attach a small protein ...
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