However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

Shanghai Helioson Pharmaceutical Co. Ltd. has synthesized molecular glue degraders comprising an E3 ubiquitin ligase coupled to a eukaryotic peptide chain release factor GTP-binding subunit ERF3A ...

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...

The Constitutive Photomorphogenesis 1 (COP1)protein is an ubiquitin E3 ligase, which targets many proteins for degradation. Until now, it has been most extensively studied for its role in repression ...

Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. My research interests ...

We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...