Without SUMO4, there is an excess of one type of signaling, disrupting other signals and preventing some repair proteins from reaching the damaged site. As a result, DNA repair fails. The significance ...

How do DNA repair mechanisms detect and repair damaged ... only UV-A and UV-B are able to penetrate Earth's atmosphere. Thus, these two types of UV radiation are of greatest concern to humans ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question.

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analysing the interactions of these ...

PRRDetect is a new algorithm that identifies tumors with faulty DNA repair, helping doctors tailor cancer treatments more ...

A number of these disorders have a definitive link to an inherited or acquired defect in one of the DNA repair pathways. Table 1 lists these disorders along with the known genetic DNA repair ...

"By specifically weakening repair mechanisms such as NER in cancer ... the research team plans to investigate how XPD detects various other types of DNA damage. More information: Jochen Kuper ...

Various intermediates in the base excision repair (BER) of a DNA base lesion (Adduct, ) are illustrated, including: an uncleaved AP site (AP site, ), a 5′-uncleaved AP site (Nicked DNA with dRP ...

Cancers with DNA repair deficiencies depend on other proteins ... prevent it from functioning could be useful for treating these types of cancer. It has already been shown that RAD52 inhibitors ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

Explore the latest findings on genetic networks and their role in DNA repair, opening new avenues for cancer therapies.

PARylation is integral to many key cellular functions, including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG ...