Cytokinesis ensures proper partitioning of genomic and cytoplasmic material between dividing cells. A key regulator of this process is the centralspindlin complex. Two recent papers report that ...

This pathway ultimately prevents the APC from targeting for proteolysis specific proteins that must be destroyed for the cell to disjoin its chromosomes, initiate cytokinesis and exit the mitotic ...

This includes an in depth molecular analysis of anillin, a highly conserved protein that is required for cytokinesis and crosslinks key components of the cell. I use cultured human cells including ...