Cartilage calcification is associated with knee osteoarthritis (OA). A study by Mitsuyama et al., however, suggests that calcification is primarily a consequence of aging rather than OA.

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

This image shows the skeleton of a skate. Most of the skeleton is made of cartilage, which is labeled in blue (1). However, parts of the skeleton are calcified, like bone, including the skull (2), ...