Beyond its role in meiosis, recombination is important to somatic cells in eukaryotes because it can be used to help repair broken DNA, even when the break involves both strands of the double helix.

ChVLig encircles the DNA as a C-shaped protein clamp. The NTase domain binds to the broken and intact DNA strands in the major groove flanking the nick and also in the minor groove on the 3’-OH side ...

DNA evidence found on the broken doorknob of a burglarized local home last year matched that of a Waterbury man with 26 previous arrests, including seven for burglaries, according to a warrant for his ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By ...

The high-resolution views provided by cryo-electron microscopy are helping scientists learn how proteins and DNA collaborate to repair broken DNA. In an eagerly awaited study, Memorial Sloan Kettering ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question.

How does DNA recombination work ... hypothesis is the finding that in induced recombination experiments, the broken ends of strands recombine with what are called ectopic homologues (areas ...