The irreversibility of cell-cycle transitions is commonly thought ... that makes a transition irreversible. Which part of the APC control network makes the switch bistable? DNA replication ...
and (c) the kinetochore protein-cell cycle machinery interface. (APC = anaphase-promoting complex, CEN = centromeric DNA, and SCF = Skp, Cullin, F-box-containing ubiquitin-ligase complex.) ...
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