Arpino is a comune in the province of Frosinone, in the Latin Valley, region of Lazio in central Italy, about 100 km southeast of Rome. Arpino occ…Arpino is a comune in the province of Frosinone, in the Latin Valley, region of Lazio in central Italy, about 100 km southeast of Rome. Arpino occupies the site of the ancient Roman city of Arpinum, which was the birthplace of notable Roman figures Gaius Marius and Marcus Tullius Cicero.